Category: Life

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It’s been 18 years since drug companies replaced pseudoephedrine with phenylephrine to keep their cold medications available over the counter when the people waging War On Drugs(tm) decided to restrict the main ingredient in Sudafed (and what it was named after) because it could be used to make meth.

Though I remember some other decongestant plugging the idea that “unlike those medications, we chose not to change our formulation…” Yeah, because you weren’t using an ingredient that got semi-banned!

From the start, the new formulation clearly wasn’t as effective. When I found out that I could still buy the real medication as long as I asked at the pharmacy counter (and showed ID so that the DEA or whoever knows I’m not trying to get around limits by hitting every pharmacy in town), I stopped bothering with the OTC versions entirely.

I wasn’t surprised when studies showed that phenylephrine doesn’t work.

Back in 2015.

(Restricting sales of the real stuff didn’t seem to make much of a dent in the meth problem, either.)

“Only” eight years later, the FDA reached the same conclusion.

And yet the industry is complaining that “if oral phenylephrine were not available over the counter, it would be a significant burden to consumers.”

HOW?????

It doesn’t work. People who buy it are wasting their time and money on snake oil instead of buying a different medication that might actually do something for them. (Not that this is a problem for the supplement industry, where “not evaluated by the FDA” might as well be a selling point.)

We all ended up worse off: cold meds that don’t work, submitting to surveillance to get the meds that do work, and it didn’t even slow down the meth epidemic.

Update: It took another year for the FDA to recommend pulling it.

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This is fascinating: Researchers looked at variations in the human leukocyte antigen (HLA) genes of people who had confirmed cases of Covid before the vaccine rollout and also had genetic records on file.

Those with a particular variation were twice as likely to have been asymptomatic.

Having that same variation from both parents made them 8.5 times as likely to have been asymptomatic!

They looked at two more cohorts and found the same results.

And then they looked at T-cells collected before the pandemic, and found that the ones with this allele responded more actively to SARS-COV2, despite never having been exposed to it before. That lends weight to the hypothesis that some people’s immune systems were able to recognize it as similar to more run-of-the-mill coronaviruses.

Next they want to broaden the study more to include people with a wider range of ancestry.

It doesn’t come close to explaining all asymptomatic cases, and they didn’t look at how it might stack with immune responses that are actually targeted at covid (vaccines, prior infections), or whether it also reduces the chances of long-term damage from covid.

But wouldn’t it be great if someone could come up with a supplement based on what this HLA variant produces that’ll cause your immune system to generalize better? Even if it’s just within coronaviruses?

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Tonight, our Star Trek: Deep Space Nine rewatch (on DVD) is up to “Bar Association”, the episode in which Rom leads all of Quark’s employees on a strike to demand better working conditions.

I swear I didn’t time this intentionally, but it seems appropriate!

Ferengi workers don’t want to stop the exploitation. We want to find a way to become the exploiters.
Rom, before deciding he’d rather stop the exploitation

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Imagine a small village near a valley, so isolated that they just call themselves “the people.” One day they find out about another village on the other side of the valley, and they start calling them “the people across the valley.” They can keep talking about “the people,” but sometimes they need to make a distinction: right now, we’re talking about the people on *this* side of the valley, not the people on both sides.

Not incidentally, the Latin prefixes for “this side of” and “the other side of” are cis- and trans-. English uses trans more frequently, as in transport, transform, transmit, transnational etc., all of which involve something crossing a divide. Sometimes it’s quite literal, like the old terms Transjordan and Cisjordan referring to the lands on the far and near sides of the Jordan river. Or more modern terms, like the cis- and trans- forms of a molecule that can have more than one structure. Or in space exploration, translunar space (beyond the moon) and cislunar (including the moon’s orbit and Lagrange points). (Who’s that contractor for the new moon missions, again?)

Come to think of it, the moon’s another good example of the same sort of thing. When we’re just talking about life here on Earth, we can say “the moon” and it’s clear which one we mean. But if we’re talking about the whole solar system, and how Earth’s moon compares to Titan or Europa, we have to specify which one we mean.

So if we’re talking about transgender people and their experience compared to non-transgender people and their experience, the clear term to use based on English grammar is cisgender, and just as transgender is often abbreviated as just “trans,” cisgender is abbreviated as “cis.”

It’s a description, just like “acoustic guitar.” They’re still guitars, but when you need to talk specifically about non-electric guitars vs. electric ones, that’s the term we use.

“Cisgender” or “cis” isn’t a slur, no matter what Twitter’s owner thinks. It’s not casting negative judgement any more than “acoustic” is casting negative judgment against the guitar, or insisting that space on one side of the moon is better than the other.

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Apparently it’s National Donut Day, and WaPo decided to look at regional differences in which chain is on top — if any.

We’re solidly in indie-land here. Even the Winchell’s I remember growing up became a mom and pop shop back in the 80s (though I think it *might* have been a Yum Yum at some point in between). I just looked it up and it’s still there, and still indie.

There are so many ex-Winchell’s in the LA/OC area that were picked up by mom-and-pop shops of all kinds that didn’t want to spend extra money replacing rounded-triangle the structure of the sign that I considered taking photos and starting a Tumblr called used-to-be-a-winchells back when Tumblr was still popular, but I never got around to it.

There’s one near where we live now that was an indie shop when we moved to the area, and had almost-but-not-quite the same name as another indie shop down the street, both using the street name as part of the shop name. The other shop changed its name to use the side street’s name instead…shortly before the ex-Winchell’s one closed. It’s now a completely different kind of business (not even a restaurant), but the sign shape is still the same!

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You wouldn’t think that books about astronomy and archaeology would have a lot in common, but Four Lost Cities (Annalee Newitz) and Under Alien Skies (Phil Plait) pack some odd similarities.

Both are about places we (mostly) can’t visit in person: Faraway planets in one case, the distant past in the other.

We have to piece together parts of the experience from what has come to us through time or through space: Telescopic observations, space probes, spectral analysis, and our understanding of physics — ruins, artifacts, aerial surveys and
what we know about people (both contemporary and in general).

For some sites we have very detailed and solid information: Angkor’s stone temples are still standing. Pompeii was well-preserved under volcanic ash and we still have first-hand writings about the city and its destruction. Mars and the moon have been extensively surveyed, including multiple landers and photographs from the surface. (And, in the case of the moon, a handful of people!)

Others require a lot of speculation: There’s a solid core of what we’ve figured out about Cahokia, but a lot of unknowns that we can sorta-kinda extrapolate from the histories and tales of surviving tribes in the area — but only to a point. Similarly, we know the rough structure of the TRAPPIST-1 solar system and some of its planets, but we have to speculate: if one of the planets in the habitable zone actually is habitable, what conditions would that require?

Both include major discoveries made within the last decade: Pluto and Charon were just a pair of dots until the New Horizons mission flew past it in 2015, bringing us pictures and measurements and so much data it took months just to download it from the probe back to Earth. Lidar surveys at Angkor in 2012 revealed the foundations of a vast metropolitan area around the temple complexes, upending our sense of how big the city was and identifying new sites to investigate.

It’s kind of funny how I read them so close together. Synchronicity and all that. They’re also both good (see also my review of Four Lost Cities and review of Under Alien Skies), and I’d definitely recommend them!

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